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KMID : 0383820100690030177
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Tuberculosis and Respiratory Diseases
2010 Volume.69 No. 3 p.177 ~ p.183
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Longitudinal Evaluation of Lung Function Associated with Emphysema in Healthy Smokers
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Sim Yun-Su
Ham Eun-Jae
Choi Kyu-Yong
Lee Suk-Young
Kim Young-Kyoon
Park Sung-Hak
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Abstract
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Background : Smoking reduces pulmonary function and induces various lung diseases. Recently, the rate of emphysema detection has increased due to lung cancer screening with low-dose chest computed tomography (CT). The purpose of this study was to evaluate changes in lung function associated with emphysema in healthy smokers.
Materials and Methods : One hundred and ninety one healthy smokers, who had undergone a low-dose chest CT (LDCT) scan as part of lung cancer screening and had revisited the health center after a median 23.9 months’ time, were recruited into this study. The severity of emphysema was calculated by the direct observation of a radiologist and a pulmonologist indipendently. Longitudinal changes in lung function according to emphysema based on LDCT and type of smoker was analyzed.
Results : Of the participants in this study, 25% of healthy smokers had emphysema, which was mild in severity, in older patients (p=0.003) and in heavy smokers (p＜0.001). FEV1/FVC and FEF25-75% were decreased in current smokers with emphysema (p=0.001 and p=0.009, respectively) and without emphysema (p=0.001 and p=0.042). Although lung function was not decreased in ex-smokers without emphysema, FEV1/FVC and FEF25-75% were decreased in ex-smoker with emphysema (p=0.020 and p=0.010).
Conclusion : Upon examination with LDCT, the prevalence of emphysema was higher in healthy smokers was than in non-smokers. Lung function was diminished in smokers with emphysema, in spite of former smoker.
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KEYWORD
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Emphysema, Tomography, X-Ray Computed, Smoking, Spirometry
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